Prohibited in competition. This compound is on the WADA Prohibited List (class [S0 / S2.3 / S2]), banned at all times, both in and out of competition. Athletes subject to WADA or USADA testing should not use it.
“The most selective GHRP available, stimulating GH release with minimal cortisol or prolactin elevation.”
Ipamorelin acts as a ghrelin mimetic, binding to the growth hormone secretagogue receptor 1a (GHS-R1a) — a Gq/11 protein-coupled receptor expressed on somatotroph cells in the anterior pituitary. GHS-R1a activation triggers phospholipase C (PLC) signaling, generating IP3 and DAG, which increases intracellular calcium and stimulates GH exocytosis. Ipamorelin’s selectivity for GH release over cortisol and prolactin is due to its specific binding conformation at GHS-R1a, which activates GH-releasing pathways without triggering adrenocorticotropic or lactotropic signaling cascades. When combined with CJC-1295 No DAC (which acts on GHRHR via the cAMP/PKA pathway), the two peptides act on distinct intracellular signaling cascades that converge on GH secretion, producing a synergistic pulse 2–10 times greater than either agent alone.
When sourcing Ipamorelin for research purposes, the following quality benchmarks should be verified before use.
>98% (verified by HPLC)
Must be provided by supplier
<0.1 EU/mg (prevents bacterial contamination)
Manufactured in cGMP-certified facility
Independent lab verification preferred
The statements made within this website have not been evaluated by the US Food and Drug Administration. The products and information provided are not intended to diagnose, treat, cure, or prevent any disease. This website is intended for educational and research purposes only. Many peptides described on this site are not approved by the FDA for human therapeutic use and are classified as research chemicals. Nothing on this site constitutes medical advice.
Demonstrated selective GH release without cortisol elevation
Shown to increase bone mineral density in animal models
Phase II clinical trials completed for post-operative ileus
A synthetic pentadecapeptide derived from gastric juice with extraordinary tissue healing properties across multiple organ systems.
A short-acting GHRH analog that produces physiological GH pulses when combined with a GHRP like Ipamorelin.
A synthetic analog of Thymosin Beta-4 that promotes systemic healing through actin regulation and angiogenesis.
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FDA Disclaimer: The statements made within this website have not been evaluated by the US Food and Drug Administration. The products and information provided are not intended to diagnose, treat, cure, or prevent any disease. This website is intended for educational and research purposes only. Many compounds described on this site are not approved by the FDA for human therapeutic use. Some are available only as compounded preparations or as materials sold for laboratory use, and several are on FDA's Category 2 list for significant safety risks. Nothing on this site constitutes medical advice or a recommendation to use any compound described.
