“A synergistic metabolic blend combining ERR agonism and NNMT inhibition for comprehensive fat loss and metabolic health.”

SLU-PP-332 activates ERRalpha and ERRgamma nuclear receptors, which regulate hundreds of genes involved in mitochondrial biogenesis, oxidative phosphorylation, and fatty acid oxidation. This creates a transcriptional program that increases mitochondrial density, enhances fat burning capacity, and promotes metabolically active muscle fiber types — essentially the molecular signature of endurance exercise adaptation. 5-Amino-1MQ inhibits NNMT (nicotinamide N-methyltransferase), an enzyme that depletes NAD+ and SAM in adipose tissue. By inhibiting NNMT, 5-Amino-1MQ raises cellular NAD+ levels, which activates SIRT1 and other sirtuins that regulate fat storage gene expression, and activates AMPK, which promotes fatty acid oxidation and inhibits lipogenesis. The combination provides complementary metabolic activation: SLU-PP-332 drives the transcriptional machinery of fat oxidation, while 5-Amino-1MQ provides the coenzyme substrate (NAD+) and signaling molecule (AMPK) needed to execute that program efficiently.