Prohibited in competition. This compound is on the WADA Prohibited List (class [S0 / S2.3 / S2]), banned at all times, both in and out of competition. Athletes subject to WADA or USADA testing should not use it.
“The only oral GH secretagogue — stimulates GH and IGF-1 through ghrelin receptor activation.”
MK-677 binds to and activates the ghrelin receptor (GHS-R1a) in the pituitary gland and hypothalamus, mimicking the action of the endogenous hunger hormone ghrelin. This activation stimulates the pituitary to release GH in pulsatile bursts, which in turn stimulates the liver to produce IGF-1 (insulin-like growth factor 1). Unlike synthetic GH, MK-677 preserves the natural pulsatile pattern of GH secretion, which is important for maintaining GH receptor sensitivity and avoiding the desensitization that can occur with continuous GH exposure. MK-677 has a half-life of approximately 24 hours, allowing for once-daily dosing. Bedtime administration aligns with the natural nocturnal GH pulse and may enhance sleep quality through GH’s effects on slow-wave sleep architecture. The compound also increases ghrelin signaling in the hypothalamus, which stimulates appetite — a common and expected effect that should be managed through dietary awareness.
Once daily (bedtime)
8–16 weeks
Bedtime dosing aligns with natural GH pulse. Start with 10 mg to assess tolerance. Increased hunger is common — manage caloric intake. Monitor IGF-1 every 3 months.
Store at room temperature, away from light and moisture.
When sourcing MK-677 (Capsule) for research purposes, the following quality benchmarks should be verified before use.
>98% (verified by HPLC)
Must be provided by supplier
<0.1 EU/mg (prevents bacterial contamination)
Manufactured in cGMP-certified facility
Independent lab verification preferred
Store at room temperature, away from light and moisture.
The statements made within this website have not been evaluated by the US Food and Drug Administration. The products and information provided are not intended to diagnose, treat, cure, or prevent any disease. This website is intended for educational and research purposes only. Many peptides described on this site are not approved by the FDA for human therapeutic use and are classified as research chemicals. Nothing on this site constitutes medical advice.
The most selective GHRP available, stimulating GH release with minimal cortisol or prolactin elevation.
Oral BPC-157 for gastrointestinal healing, gut permeability, and systemic anti-inflammatory effects.
Category
Hormone & GH
Status
Dose
Frequency
Once daily (bedtime)
Cycle
8–16 weeks
Peptides
Protocols
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FDA Disclaimer: The statements made within this website have not been evaluated by the US Food and Drug Administration. The products and information provided are not intended to diagnose, treat, cure, or prevent any disease. This website is intended for educational and research purposes only. Many compounds described on this site are not approved by the FDA for human therapeutic use. Some are available only as compounded preparations or as materials sold for laboratory use, and several are on FDA's Category 2 list for significant safety risks. Nothing on this site constitutes medical advice or a recommendation to use any compound described.
