Selank

Description

Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) developed at the Institute of Molecular Genetics of the Russian Academy of Sciences as an analog of tuftsin (a natural immunomodulatory tetrapeptide). It has been approved in Russia and Ukraine for the treatment of generalized anxiety disorder and as a nootropic agent. Selank is notable for producing robust anxiolytic effects comparable to benzodiazepines in animal models, but without the sedation, cognitive impairment, tolerance development, or withdrawal syndrome associated with benzodiazepine use. This makes it particularly attractive for long-term anxiety management and cognitive enhancement. It has also demonstrated immunomodulatory properties, increasing the activity of natural killer (NK) cells and T-lymphocytes, and has been studied for antiviral effects.

Key Characteristics

Investigated Benefits

• Reduced anxiety without sedation
• Improved cognitive function
• Enhanced memory and learning
• No tolerance or dependence
• Immunomodulatory effects

* Benefits based on preclinical/animal research unless otherwise noted.

Mechanism of Action

Selank’s anxiolytic mechanism involves multiple neurotransmitter systems. It modulates the GABAergic system by increasing the expression of GABA-A receptor subunits, enhancing inhibitory neurotransmission without directly binding to benzodiazepine sites (which explains the absence of tolerance and dependence). It also influences serotonin metabolism by inhibiting enkephalin-degrading enzymes, increasing the availability of endogenous opioid peptides that modulate anxiety. Selank increases BDNF (brain-derived neurotrophic factor) expression in the hippocampus and prefrontal cortex, supporting neuroplasticity and cognitive function. Its tuftsin-like structure confers immunomodulatory effects: it activates T-lymphocytes and NK cells through tuftsin receptors on immune cells, and has demonstrated antiviral properties in influenza models. Intranasal administration provides rapid CNS delivery through olfactory nerve pathways.

Reconstitution Guide

Available as nasal spray. Injectable: add 1 mL bacteriostatic water to 1 mg vial.

Research Highlights

1. 1Approved in Russia for anxiety disorders
2. 2Demonstrated anxiolytic effects comparable to diazepam in animal models
3. 3Increased BDNF expression in multiple studies

Compatible Peptides

Peptides commonly used alongside Selank for synergistic effects.