A long-acting analog of IGF-1 with enhanced receptor binding and extended half-life for anabolic and recovery effects.
IGF-1 LR3 is a recombinant analog of insulin-like growth factor-1 with an arginine substitution at position 3 and an N-terminal 13 amino acid extension. These modifications reduce binding to IGF-binding proteins, extending its half-life from ~12 minutes to ~20 hours and enhancing its biological activity.
* Benefits based on preclinical/animal research unless otherwise noted.
IGF-1 LR3 binds to IGF-1 receptors throughout the body, activating PI3K/Akt and MAPK signaling pathways that promote cell growth, protein synthesis, and anti-apoptotic effects. It stimulates satellite cell activation for muscle repair and promotes glucose uptake.
Protocol Notes: Use in short cycles (4–6 weeks) with equal breaks to prevent receptor desensitization. Post-workout injection maximizes anabolic effects. Monitor blood glucose — can cause hypoglycemia.
Add 1 mL bacteriostatic water to 1 mg vial → 1000 mcg/mL For 50 mcg dose: draw 0.05 mL (5 units on U-100 syringe)
When sourcing IGF-1 LR3 for research purposes, the following quality benchmarks should be verified before use.
Lyophilized: refrigerate. Reconstituted: refrigerate and use within 14 days.
The statements made within this website have not been evaluated by the US Food and Drug Administration. The products and information provided are not intended to diagnose, treat, cure, or prevent any disease. This website is intended for educational and research purposes only. Many peptides described on this site are not approved by the FDA for human therapeutic use and are classified as research chemicals. Nothing on this site constitutes medical advice.
Moderate Evidence — Multiple animal studies and/or early human trials. Reasonable confidence in mechanism, but human data is limited.
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