Tesamorelin / Ipamorelin

Tesamorelin / Ipamorelin Combination

A synergistic GHRH + GHRP combination for enhanced GH pulsatility and visceral fat reduction.

100% 50% · t½ Time → Serum level
Molecular Weight Not specified
Half-Life Varies
Typical Dose 0.75 mg to 2.25 mg
Cycle Length 8–16 weeks

Description

This combination pairs Tesamorelin (GHRH analog) with Ipamorelin (GHRP) for synergistic GH release. Tesamorelin provides the GHRH stimulus while Ipamorelin amplifies the GH pulse through GHS-R1a, resulting in greater GH secretion than either alone.

Key Characteristics

Molecular Formula

Molecular Weight

Half-Life

Administration Routes

Subcutaneous injection

Typical Dose

0.75 mg to 2.25 mg

Frequency

Daily (bedtime preferred)

Investigated Benefits

* Benefits based on preclinical/animal research unless otherwise noted.

Mechanism of Action

“A synergistic GHRH + GHRP combination for enhanced GH pulsatility and visceral fat reduction.”

Tesamorelin activates GHRH receptors to stimulate GH synthesis. Ipamorelin activates GHS-R1a to amplify the GH pulse. The dual mechanism produces 3–5x greater GH release than either peptide alone.

Administration Routes

Subcutaneous injection

Key Characteristics

Typical Dose

0.75 mg to 2.25 mg

Frequency

Daily (bedtime preferred)

Cycle Length

8–16 weeks

Administration

Subcutaneous injection

Protocol Notes

Administer on empty stomach. Bedtime dosing maximizes natural GH pulse. Monitor IGF-1 levels every 3 months.

Reconstitution Guide

Per prescriber instructions.

Storage Information

Lyophilized: refrigerate. Reconstituted: refrigerate and use within 30 days.

Quality & Sourcing Standards

When sourcing Tesamorelin / Ipamorelin for research purposes, the following quality benchmarks should be verified before use.

Purity:

>98% (verified by HPLC)

Certificate of Analysis (COA):

Must be provided by supplier

Endotoxin Testing:

<0.1 EU/mg (prevents bacterial contamination)

GMP Compliance:

Manufactured in cGMP-certified facility

Third-Party Testing:

Independent lab verification preferred

Storage Information

Lyophilized: refrigerate. Reconstituted: refrigerate and use within 30 days.

FDA Disclaimer

The statements made within this website have not been evaluated by the US Food and Drug Administration. The products and information provided are not intended to diagnose, treat, cure, or prevent any disease. This website is intended for educational and research purposes only. Many peptides described on this site are not approved by the FDA for human therapeutic use and are classified as research chemicals. Nothing on this site constitutes medical advice.

Research Highlights

1

Tesamorelin FDA-approved for HIV-associated lipodystrophy

2

Ipamorelin demonstrated selective GH release without cortisol elevation

3

Combination produces synergistic GH pulse

Evidence Level

Multiple animal studies and/or early human trials. Reasonable confidence in mechanism, but human data is limited.

Compatible Peptides

Peptides commonly used alongside Tesamorelin / Ipamorelin / MGF for synergistic effects.

BPC-157

A synthetic pentadecapeptide derived from gastric juice with extraordinary tissue healing properties across multiple organ systems.

TB-500

A synthetic analog of Thymosin Beta-4 that promotes systemic healing through actin regulation and angiogenesis.

Quick Reference

Category

Blends & Combos

Status

Research Only

Dose

0.75 mg to 2.25 mg

Frequency

Daily (bedtime preferred)

Cycle

8–16 weeks